Amazing Formulas Grapeseed Extract Supplement | 100 In Pakistan

Amazing Formulas Grapeseed Extract Supplement | 100  In Pakistan | Buy Now

Complementary and Integrative Therapies for ENT Disorders
James M. Hamilton MD, Edmund A. Pribitkin MD, in 
Otolaryngologic Clinics of North America
, 2013

Grape seed extract
Grape seed extract (Vitis vinifera, Vitis coignetiae) has been used to treat venous insufficiency, inflammatory conditions, and promote wound healing in Europe. It is also known as

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Pine bark

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Pinus maritima

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Grape complex

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Grape seed

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Grape seed oil

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Grape skin extract

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Muskat

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ActiVin

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Endotelon

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Grape seed standardized extract

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Leucoselect-phytosome

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Masquelier's Original OPCs

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Pycnogenol

It has been established as a potent antioxidant because of its constituent oligomeric proanthocyanidins and thought to exhibit a wide range of biologic, pharmacologic, chemoprotective, and antioxidant activity. Additionally, proanthocyanidins are thought to have the capacity to stabilize collagen and elastin, thereby improving the elasticity, flexibility, and appearance of the skin.23

Motivated by encouraging results in vitro and in animal models, grape seed, its oil, and its extract have been increasingly used for strengthening vessels and preventing bruising.12 The extract has been reported to increase wound contraction and closure speed in mice, vascular endothelial growth factor (VEGF) and tenascin levels in the wound edge, and connective tissue deposition. A 2001 in vitro study by Khanna and colleagues36 reported evidence showing that grape seed proanthocyanidin extract (containing resveratrol) facilitates oxidant-induced VEGF expression in keratinocytes. VEGF induces the migration and proliferation of endothelial cells and enhances vascular permeability consistent with the purported ability to promote angiogenesis. Angiogenesis plays a central role in wound healing.36

A 2002 study by Khanna and colleagues37 examined the effect of topical grape seed proanthocyanidin extract (GSPE) on the healing of full-thickness excisional wounds in the mouse model. GSPE treatment was associated with a more well-defined hyperproliferative epithelial region, higher cell density, enhanced deposition of connective tissue, and improved histologic architecture in treated wounds compared with control wounds in the same animal. GSPE treatment also increased VEGF and tenascin expression in the wound edge tissue, which are markers in granulation tissue often used as indicators of cutaneous wound repair.37

A 2010 study by Nayak and colleagues38 of the wound-healing activity in mice of a finely ground grape-skin powder derived from the Cabernet Sauvignon variety demonstrated that animals in the treatment group exhibited significant increases in the rate of wound contraction (100% by day 13 when compared with control [82.1%] and standard treatment with mupirocin [93.0%]) and an increased rate of epithelialization. Similarly, a 2004 study by Blazsó and colleagues39 demonstrated that regular topical application of Pycnogenol, a patented nutrient supplement extracted from the bark of European coastal pine Pinus maritime that consists of flavonoids, catechins, procyanidins, and phenolic acids (which are the same constituents found in grape seed, although it is not the same supplement),40 accelerated wound healing and reduced scar formation in rats. Gels of increasing concentration (1%, 2%, and 5%) were applied to wounds inflicted on the backs of the animals with a 100°C branding iron. The 1% gel significantly shortened the wound healing time by 1.6 days, the 2% gel reduced the time by 2.7 days, and the 5% gel by 5.3 days. Pycnogenol also reduced the diameter of the scars remaining following complete scab loss in a concentration-dependent manner.39